Tackling endothelium remodeling in cardiovascular disease
Autores da FMUP
Participantes de fora da FMUP
- Gul'asová, Z
- Guerreiro, SG
- Link, R
- Tomecková, V
Unidades de investigação
Abstract
Endothelial dysfunction is considered an early marker of atherosclerosis. Herein, we address the molecular mechanisms affecting endothelium remodeling in disease. Vascular calcification is highly prevalent in patients with ischemic cardiovascular disease, cerebrovascular disorder, and renal failure, being a common feature in aging, diabetes, dyslipidemia, abnormal valve biomechanics, end-stage renal disease and atherosclerosis, a major cause of mortality and morbidity. Oxidative stress promotes calcification of vascular smooth muscle cells (SMC) by increasing osteogenic transcription factors expression and activity in atherosclerotic plaques. Various markers of osteogenic differentiation are expressed by SMC in calcified atherosclerotic lesions. Interestingly, decreased levels of some bone factors and microRNAs accelerate vascular calcification and injured tissue regeneration. Another key player in endothelial remodeling is amino acids metabolism. Branched-chain amino acids are catabolized in several nonhepatic tissues including cardiac muscle. Immune activation and inflammation in cardiovascular disease patients associate with higher phenylalanine/tyrosine ratios. Understanding the whole process that underlies endothelium dysfunction is of paramount importance for the development of new therapeutic approaches.
Dados da publicação
- ISSN/ISSNe:
- 0730-2312, 1097-4644
- Tipo:
- Article
- Páginas:
- 938-945
- DOI:
- 10.1002/jcb.29379
- Link para outro recurso:
- www.scopus.com
Journal of Cellular Biochemistry Wiley-Liss Inc.
Citações Recebidas na Web of Science: 6
Citações Recebidas na Scopus: 7
Documentos
- Não há documentos
Filiações
Keywords
- alkaline phosphatase; amino acids; atherosclerosis; bone factors; epigenetic; nitric oxide; vascular calcification
Proyectos asociados
Effects of Xanthohumol on Metabolic Syndrome Progression (XAN4Health) - NCT03561116
Investigador Principal: Raquel Ângela Silva Soares Lino
Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019
Citar a publicação
Gul'asová Z,Guerreiro SG,Link R,Soares R,Tomecková V. Tackling endothelium remodeling in cardiovascular disease. J. Cell. Biochem. 2020. 121. (2):p. 938-945. IF:4,429. (2).