Serum inflammatory biomarkers are associated with increased choroidal thickness in keratoconus

Data de publicação:

Autores da FMUP

  • Raquel Ângela Silva Soares Lino

    Autor

Participantes de fora da FMUP

  • Pinheiro Costa, J
  • Fontes, ML
  • Luis, C
  • Martins, S
  • Madeira, D
  • Falc?o Reis, F.
  • Carneiro, ?.

Unidades de investigação

Abstract

Inflammation may play a significant role in Keratoconus (KC), but the relationship between inflammatory markers and choroidal thickness (CT) is unknown. The purpose of this study was to evaluate serum inflammatory markers and correlate them with the choroidal profile of KC patients and control subjects. Forty patients with KC and 26 age-matched control subjects were enrolled in a cross-sectional case-control study. Choroidal profile was studied with a Spectralis Heidelberg apparatus and venous blood samples were collected. Neutrophil/lymphocyte ratio (NLR), monocyte/HDL ratio (MHR), platelet/lymphocyte ratio (PLR) and systemic immune inflammation index (SII) were calculated. Serum inflammatory biomarkers IL-1, IL-6 and TNF-alfa were also analyzed. KC group presented thicker choroids in each evaluated point when compared to the control group (subfoveal CT 417.38 PLUSMN; 79.79 vs 299.61 PLUSMN; 76.13, p < 0.001 for all measured locations). Mean values of NLR, PLR and SII were significantly higher in patients with KC (NLR p = 0.001; PLR p = 0.042; SII p = 0.007). Although KC patients presented higher mean levels of MHR, IL-1, IL-6 and TNF- alpha; than control group, no significant differences were achieved. Positive correlations were found between subfoveal CT and NLR and SII (0.408, p = 0.001 and 0.288, p = 0.019 respectively). The results presented are in favor of a relationship between the increased CT and inflammatory mechanisms in KC patients. The elevated serum inflammatory indices NLR, SII and PLR provide additional evidence of a role for systemic inflammation in the pathophysiology of KC.

Dados da publicação

ISSN/ISSNe:
2045-2322, 2045-2322

Scientific Reports  Nature Publishing Group

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 5

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Keywords

  • Biomarkers; Case-Control Studies; Choroid; Cross-Sectional Studies; Humans; Inflammation; Interleukin-1; Interleukin-6; Keratoconus; Lymphocytes; Neutrophils; Retrospective Studies; Tumor Necrosis Factor-alpha; biological marker; interleukin 1; interleukin 6; tumor necrosis factor; case control study; choroid; cross-sectional study; human; inflammation; keratoconus; lymphocyte; neutrophil; retrospective study

Proyectos asociados

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Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019

SARS-CoV-2 e Angiogénese: uma ligação por explicar

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Estudo Clínico Académico . 2021

The use of targeted angiogenic therapies for ischemic diabetic foot ulcer repair.

Investigador Principal: Raquel Ângela Silva Soares Lino

Estudo Clínico Académico . 2022

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