Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the oxidative status in circulating lipoproteins

Data de publicação:

Autores da FMUP

  • Raquel Ângela Silva Soares Lino

    Autor

Participantes de fora da FMUP

  • Reis, A
  • Rocha, S
  • Dias, IHK
  • Costa, R
  • Sanchez-Quesada, JL
  • Perez, A
  • Freitas, V.

Unidades de investigação

Abstract

The incidence of diabetes on the worldwide population has tripled in the past 5 decades. While drug-based therapies are valuable strategies to treat and ease the socio-economic burden of diabetes, nutritional strategies offer valuable alternatives to prevent and manage diabetes onset and contribute to the sustainability of health budgets. Whilst, intervention studies have shown that (poly)phenol-rich diets improve fasting glucose levels and other blood parameters, very little is known about the distribution of ingested polyphenols in circulation and the impact of diabetes on its cargo. In this study we investigate the impact of type 2 diabetes on the cargo of plasma (poly)phenols. Our results show that phenolic compounds are heterogeneously distributed in circulation though mainly transported by lipoprotein populations. We also found that diabetes has a marked effect on the phenolic content transported by VLDL resulting in the decrease in the content of flavonoids and consequently a decrease in the antioxidant capacity. In addition to the reduced bioavailability of (poly)phenol metabolites and increase of oxidative status in LDL and HDL populations in diabetes, cell-based assays show that sub-micromolar amounts of microbial (poly) phenol metabolites are able to counteract the pro-inflammatory status in glucose-challenged endothelial cells. Our findings highlight the relevance of triglyceride-rich lipoproteins in the transport and delivery of bioactive plant-based compounds to the endothelium in T2DM supporting the adoption of nutritional guidelines as an alternative strategy to drug-based therapeutic approaches.

Dados da publicação

ISSN/ISSNe:
2213-2317, 2213-2317

Redox Biology  Elsevier BV

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 6

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Keywords

  • Diabetes Mellitus, Type 2; Endothelial Cells; Glucose; Humans; Lipoproteins; Metabolome; Oxidative Stress; Phenol; Phenols; flavonoid; glucose; high density lipoprotein; lipoprotein; polyphenol; triacylglycerol; very low density lipoprotein; glucose; lipoprotein; phenol; phenol derivative; adult; alternative medicine; antioxidant activity; Article; bioavailability; blood level; cell assay; clinical article; controlled study; endothelium; endothelium cell; enzyme metabolism; female; human; human cell; male; middle aged; non insulin dependent diabetes mellitus; nutritional support; metabolome; oxidative stress

Proyectos asociados

Effects of Xanthohumol on Metabolic Syndrome Progression (XAN4Health) - NCT03561116

Investigador Principal: Raquel Ângela Silva Soares Lino

Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019

SARS-CoV-2 e Angiogénese: uma ligação por explicar

Investigador Principal: Raquel Ângela Silva Soares Lino

Estudo Clínico Académico . 2021

The use of targeted angiogenic therapies for ischemic diabetic foot ulcer repair.

Investigador Principal: Raquel Ângela Silva Soares Lino

Estudo Clínico Académico . 2022

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