Helicobacter pylori infection: from standard to alternative treatment strategies

Autores da FMUP
Participantes de fora da FMUP
- Ferreira, R
- Azevedo, N.
- Oleastro, M
- Azeredo, J
- Melo, LDR
Unidades de investigação
Abstract
Helicobacter pylori is the major component of the gastric microbiome of infected individuals and one of the aetiological factors of chronic gastritis, peptic ulcer disease and gastric cancer. The increasing resistance to antibiotics worldwide has made the treatment of H. pylori infection a challenge. As a way to overhaul the efficacy of currently used H. pylori antibiotic-based eradication therapies, alternative treatment strategies are being devised. These include probiotics and prebiotics as adjuvants in H. pylori treatment, antimicrobial peptides as alternatives to antibiotics, photodynamic therapy ingestible devices, microparticles and nanoparticles applied as drug delivery systems, vaccines, natural products, and phage therapy. This review provides an updated synopsis of these emerging H. pylori control strategies and discusses the advantages, hurdles, and challenges associated with their development and implementation. An effective human vaccine would be a major achievement although, until now, projects regarding vaccine development have failed or were discontinued. Numerous natural products have demonstrated anti-H. pylori activity, mostly in vitro, but further clinical studies are needed to fully disclose their role in H. pylori eradication. Finally, phage therapy has the potential to emerge as a valid alternative, but major challenges remain, namely the isolation of more H. pylori strictly virulent bacterio(phages).
Dados da publicação
- ISSN/ISSNe:
- 1549-7828, 1040-841X
- Tipo:
- Article
- Páginas:
- 376-396
- Link para outro recurso:
- www.scopus.com
Critical Reviews in Microbiology Informa Healthcare
Citações Recebidas na Web of Science: 24
Citações Recebidas na Scopus: 47
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Keywords
- Helicobacter pylori; antibiotic resistance; alternative treatments
Proyectos asociados
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Estudo Clínico Académico (Helicobacter) . 2019
Immune checkpoint inhibitors for the treatment of gastric cancer
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico . 2021
Evaluation of the use of Helicobacter pylori genotypes and gastric microbiota markers to identify individuals at high risk of gastric carcinoma
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico . 2021
Citar a publicação
Sousa C,Ferreira R,Azevedo N,Oleastro M,Azeredo J,Figueiredo C,Melo LDR. Helicobacter pylori infection: from standard to alternative treatment strategies. Crit. Rev. Microbiol. 2022. 48. (3):p. 376-396. IF:6,500. (1).