Shedding Light on the African Enigma: In Vitro Testing of Homo sapiens-Helicobacter pylori Coevolution

Autores da FMUP
Participantes de fora da FMUP
- Bruno Cavadas
- Marina Leite
- Nicole Pedro
- Ana C. Magalh?es
- Joana Melo
- Marcelo Correia
- Camacho, R.
- Fonseca, N.
- Lu?sa Pereira
Unidades de investigação
Abstract
The continuous characterization of genome-wide diversity in population and case-cohort samples, allied to the development of new algorithms, are shedding light on host ancestry impact and selection events on various infectious diseases. Especially interesting are the long-standing associations between humans and certain bacteria, such as the case of Helicobacter pylori, which could have been strong drivers of adaptation leading to coevolution. Some evidence on admixed gastric cancer cohorts have been suggested as supporting Homo-Helicobacter coevolution, but reliable experimental data that control both the bacterium and the host ancestries are lacking. Here, we conducted the first in vitro coinfection assays with dual human- and bacterium-matched and -mismatched ancestries, in African and European backgrounds, to evaluate the genome wide gene expression host response to H. pylori. Our results showed that: (1) the host response to H. pylori infection was greatly shaped by the human ancestry, with variability on innate immune system and metabolism; (2) African human ancestry showed signs of coevolution with H. pylori while European ancestry appeared to be maladapted; and (3) mismatched ancestry did not seem to be an important differentiator of gene expression at the initial stages of infection as assayed here.
Dados da publicação
- ISSN/ISSNe:
- 2076-2607, 2076-2607
- Tipo:
- Article
- Páginas:
- 1-18
- Link para outro recurso:
- www.scopus.com
Microorganisms MDPI AG
Citações Recebidas na Web of Science: 8
Citações Recebidas na Scopus: 10
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Keywords
- coevolution; Helicobacter pylori; Homo sapiens; genome-wide gene expression; ancestry background; innate immune response
Proyectos asociados
Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico (Helicobacter) . 2019
Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla
Investigador Principal: Valdemar de Jesus Conde Máximo
Estudo Clínico Académico (Mitochondrial) . 2020
Citar a publicação
Bruno C,Marina L,Nicole P,Ana C,Joana M,Marcelo C,Conde V,Camacho R,Fonseca N,Figueiredo C,Lu?sa P. Shedding Light on the African Enigma: In Vitro Testing of Homo sapiens-Helicobacter pylori Coevolution. Microorg. 2021. 9. (2):p. 1-18. IF:4,926. (2).