Shedding Light on the African Enigma: In Vitro Testing of Homo sapiens-Helicobacter pylori Coevolution

Data de publicação:

Autores da FMUP

  • Valdemar De Jesus Conde Máximo

    Autor

  • Maria Do Céu Fontes Herdeiro Figueiredo

    Autor

Participantes de fora da FMUP

  • Bruno Cavadas
  • Marina Leite
  • Nicole Pedro
  • Ana C. Magalh?es
  • Joana Melo
  • Marcelo Correia
  • Camacho, R.
  • Fonseca, N.
  • Lu?sa Pereira

Unidades de investigação

Abstract

The continuous characterization of genome-wide diversity in population and case-cohort samples, allied to the development of new algorithms, are shedding light on host ancestry impact and selection events on various infectious diseases. Especially interesting are the long-standing associations between humans and certain bacteria, such as the case of Helicobacter pylori, which could have been strong drivers of adaptation leading to coevolution. Some evidence on admixed gastric cancer cohorts have been suggested as supporting Homo-Helicobacter coevolution, but reliable experimental data that control both the bacterium and the host ancestries are lacking. Here, we conducted the first in vitro coinfection assays with dual human- and bacterium-matched and -mismatched ancestries, in African and European backgrounds, to evaluate the genome wide gene expression host response to H. pylori. Our results showed that: (1) the host response to H. pylori infection was greatly shaped by the human ancestry, with variability on innate immune system and metabolism; (2) African human ancestry showed signs of coevolution with H. pylori while European ancestry appeared to be maladapted; and (3) mismatched ancestry did not seem to be an important differentiator of gene expression at the initial stages of infection as assayed here.

Dados da publicação

ISSN/ISSNe:
2076-2607, 2076-2607

Microorganisms  MDPI AG

Tipo:
Article
Páginas:
1-18
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 8

Citações Recebidas na Scopus: 10

Documentos

  • Não há documentos

Métricas

Filiações

Filiações não disponíveis

Keywords

  • coevolution; Helicobacter pylori; Homo sapiens; genome-wide gene expression; ancestry background; innate immune response

Proyectos asociados

Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions

Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo

Estudo Clínico Académico (Helicobacter) . 2019

Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla

Investigador Principal: Valdemar de Jesus Conde Máximo

Estudo Clínico Académico (Mitochondrial) . 2020

Citar a publicação

Partilhar a publicação