Portal de investigação
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Monteiro, I
- Missiaglia, E
- Sciarra, A
- Bouilly, J
- Romero, P
- Sempoux, C
- de Leval, L
Unidades de investigação
Abstract
CD73 converts AMP to adenosine, an immunosuppressive metabolite that promotes tumorigenesis. This study presents a systematic evaluation of CD73 expression in benign, hyperplastic, and neoplastic thyroid. CD73 expression was assessed by immunohistochemistry in 142 thyroid samples. CD73 was expressed in normal thyroid (3/6) and goiter (5/6), with an apical pattern and mild intensity. Apical and mild CD73 expression was also present in oncocytic cell adenomas/carcinomas (9/10; 5/8) and in follicular adenomas/carcinomas (12/18; 23/27). In contrast, papillary thyroid carcinomas featured extensive and intense CD73 staining (49/50) (vs. normal thyroid/goiter, p < 0.001). Seven of nine anaplastic carcinomas were CD73-positive with heterogeneous extensiveness of staining. Medullary and poorly differentiated carcinomas were mostly CD73-negative (1/6; 2/2). These results were corroborated by NT5E mRNA profiling. Papillary carcinomas feature enhanced CD73 protein and mRNA expression with distinct and intense staining, more pronounced in the invasive fronts of the tumors.
Dados da publicação
- ISSN/ISSNe:
- 0945-6317, 1432-2307
- Tipo:
- Article
- Páginas:
- 209-214
- Link para outro recurso:
- www.scopus.com
VIRCHOWS ARCHIV Springer Verlag
Citações Recebidas na Web of Science: 5
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- CD73; Immunohistochemistry; Thyroid adenoma; Thyroid carcinoma; Papillary thyroid carcinoma
Campos de estudo
Financiamento
Proyectos asociados
Equidade em saúde: um inquérito a especialistas e análise de saúde auto-percecionada.
Investigador Principal: João Vasco Nunes dos Santos
Estudo Observacional Académico (EquiSaude) . 2021
Citar a publicação
Monteiro I,Missiaglia E,Sciarra A,Santos JV,Bouilly J,Romero P,Sempoux C,de Leval L. CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas. Virchows Arch. 2021. 479. (1):p. 209-214. IF:4,535. (2).
