Association between bisphenol A exposure and cardiometabolic outcomes: A longitudinal approach

Data de publicação:

Autores da FMUP

  • Milton Severo Barros Da Silva

    Autor

  • Carla Maria De Moura Lopes

    Autor

Participantes de fora da FMUP

  • Costa, S.A.
  • Torres, D.

Unidades de investigação

Abstract

Increased cardiometabolic risk is associated with abnormalities in blood biomarkers profile and adiposity measurements. Some substances found in the food matrix and the environment, called endocrine-disrupting chemicals, may impair cardiometabolic health in the early and later stages of life. Bisphenol A (BPA) is a food contaminant that migrates from food contact materials and may act as an endocrine disruptor, negatively affecting human health. The present work aims to longitudinally assess the association between BPA exposure and cardiometabolic outcomes, considering data from Portuguese population-based birth cohort Generation XXI. Blood insulin (0.06std?; 95 %CI:0.03,0.09) and insulin resistance (0.05std?; 95 %CI:0.02,0.08) presented a significant longitudinal association with BPA daily exposure after adjustment for important variables and energy. The same findings were observed for fat mass (0.03std?; 95 %CI 0.01,0.06) and waist circumference (0.06std?; 95 %CI:0.04,0.08). For z-BMI, a significant cross-sectional (0.03std?; 95 %CI:0.01,0.04) and longitudinal (0.02std?; 95 %CI:0.00,0.04) association was found. This was the first study assessing the association between BPA exposure and health outcomes from childhood to adolescence. We found an association between BPA exposure and increased blood insulin level, insulin resistance, fat mass percentage, waist circumference and z-BMI. Our results point to the need to reduce exposure to BPA in the early stages of life. ? 2024 The Authors

Dados da publicação

ISSN/ISSNe:
0304-3894, 1873-3336

Journal of Hazardous Materials  Elsevier

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 1

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Keywords

  • Adolescent; Adult; Benzhydryl Compounds; Cardiovascular Diseases; Child; Endocrine Disruptors; Environmental Exposure; Environmental Pollutants; Female; Humans; Insulin; Insulin Resistance; Longitudinal Studies; Male; Phenols; Portugal; Waist Circumference; Biomarkers; Blood; Chemical contamination; Endocrine disrupters; Forestry; Nutrition; Phenols; Population statistics; 4,4' isopropylidenediphenol; insulin; 4,4' isopropylidenediphenol; benzhydryl derivative; endocrine disruptor; insulin; phenol derivative; Bisphenol A; Bisphenols-A; Cohort; Fat mass; Food contaminants; Food matrixes; Health outcomes; Insulin resistance; Random forests; Urinary biomarkers; abnormality; biomarker; cardiovascular disease; cohort analysis; dye; food waste; health risk; pollution exposure; urine; adolescence; adult; Article; birth cohort; body mass; caloric intake; cardiometabolic risk; childhood; cohort analysis; controlled study; cross-sectional study; fat mass; female; follow up; homeostasis model ass

Proyectos asociados

Tracking the acquisition of eating habits in children and its effects on behaviours related to appetite

Investigador Principal: Carla Maria de Moura Lopes

Estudo Clínico Académico . 2019

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