Harnessing the Microbiome to Reduce Pancreatic Cancer Burden

Autores da FMUP
Participantes de fora da FMUP
- Bastos, AR
- Pereira-Marques, J
- Ferreira, RM
Unidades de investigação
Abstract
Simple Summary: Pancreatic cancer has one of the worst prognoses among all the malignancies. To date, there are no effective strategies for preventing, diagnosing, or treating this aggressive disease. Increasing evidence shows that the human microbiome influences pancreatic cancer development and the response to treatment, which is the main aim of this review. Future studies will be key to determining whether or not this knowledge might be used to develop new strategies that harness the microbiome for diagnostic and therapeutic interventions in pancreatic cancer.Pancreatic cancer mortality is expected to rise in the next decades. This aggressive malignancy has a dismal prognosis due to late diagnosis and resistance to treatment. Increasing evidence indicates that host-microbiome interactions play an integral role in pancreatic cancer development, suggesting that harnessing the microbiome might offer promising opportunities for diagnostic and therapeutic interventions. Herein, we review the associations between pancreatic cancer and the intratumoral, gut and oral microbiomes. We also explore the mechanisms with which microbes influence cancer development and the response to treatment. We further discuss the potentials and limitations of using the microbiome as a target for therapeutic interventions, in order to improve pancreatic cancer patient outcomes.
Dados da publicação
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Review
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Cancers Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 6
Documentos
- Não há documentos
Filiações
Keywords
- microbiome; pancreatic cancer; pancreatic ductal adenocarcinoma; carcinogenesis; therapy response
Financiamento
Proyectos asociados
Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico (Helicobacter) . 2019
Immune checkpoint inhibitors for the treatment of gastric cancer
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico . 2021
Evaluation of the use of Helicobacter pylori genotypes and gastric microbiota markers to identify individuals at high risk of gastric carcinoma
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico . 2021
Citar a publicação
Bastos AR,Pereira J,Ferreira RM,Figueiredo C. Harnessing the Microbiome to Reduce Pancreatic Cancer Burden. Cancers. 2023. 15(9):2629. IF:5,200. (2).