Association between blood pressure and angiotensin-converting enzymes activity in prepubertal children*

Data de publicação:

Autores da FMUP

  • Andreia Sofia Costa Teixeira

    Autor

  • Teresa Maria De Jesus Teixeira De Sousa

    Autor

Participantes de fora da FMUP

  • Gaspar, AR
  • Andrade, B
  • Mosca, S
  • Ferreira-Duarte, M
  • Cosme, D
  • Albino-Teixeira, A
  • Ronchi, FA
  • Leite, AP
  • Casarini, DE
  • Areias, J.
  • Afonso, AC
  • Morato, M.
  • Correia-Costa, L

Unidades de investigação

Abstract

Objectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Generation XXI (Portugal). Anthropometric measurements and 24-h ambulatory BP monitoring were performed. ACE and ACE2 activities were quantified by fluorometric methods.Results:Overweight/obese children demonstrated significantly higher ACE and ACE2 activities, when compared to their normal weight counterparts [median (P25-P75), ACE: 39.48 (30.52-48.97) vs. 42.90 (35.62-47.18) vs. 43.38 (33.49-49.89) mU/ml, P for trend = 0.009; ACE2: 10.41 (7.58-15.47) vs. 21.56 (13.34-29.09) vs. 29.00 (22.91-34.32) pM/min per ml, P for trend < 0.001, in normal weight, overweight and obese children, respectively]. In girls, night-time systolic BP (SBP) and diastolic BP (DBP) increased across tertiles of ACE activity (P < 0.001 and P = 0.002, respectively). ACE2 activity was associated with higher night-time SBP and DBP in overweight/obese girls (P = 0.037 and P = 0.048, respectively) and night-time DBP in the BMI z-score girl adjusted model (P = 0.018). Median ACE2 levels were significantly higher among nondipper girls (16.7 vs. 11.6 pM/min per ml, P = 0.009).Conclusions:Our work shows that obesity is associated with activation of the renin-angiotensin-aldosterone system, with significant increase of ACE and ACE2 activities already in childhood. Also, we report sex differences in the association of ACE and ACE2 activities with BP.

Dados da publicação

ISSN/ISSNe:
1473-5598, 0263-6352

Journal of Hypertension  Lippincott Williams and Wilkins Ltd.

Tipo:
Article
Páginas:
545-553
Link para outro recurso:
www.scopus.com

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Keywords

  • angiotensin-converting enzyme; angiotensin-converting enzyme 2; obesity; renin-angiotensin-aldosterone system; sex

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Proyectos asociados

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