Portal de investigação
Association between blood pressure and angiotensin-converting enzymes activity in prepubertal children*
Autores da FMUP
Participantes de fora da FMUP
- Gaspar, AR
- Andrade, B
- Mosca, S
- Ferreira-Duarte, M
- Cosme, D
- Albino-Teixeira, A
- Ronchi, FA
- Leite, AP
- Casarini, DE
- Areias, J.
- Afonso, AC
- Morato, M.
- Correia-Costa, L
Unidades de investigação
Abstract
Objectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Generation XXI (Portugal). Anthropometric measurements and 24-h ambulatory BP monitoring were performed. ACE and ACE2 activities were quantified by fluorometric methods.Results:Overweight/obese children demonstrated significantly higher ACE and ACE2 activities, when compared to their normal weight counterparts [median (P25-P75), ACE: 39.48 (30.52-48.97) vs. 42.90 (35.62-47.18) vs. 43.38 (33.49-49.89) mU/ml, P for trend = 0.009; ACE2: 10.41 (7.58-15.47) vs. 21.56 (13.34-29.09) vs. 29.00 (22.91-34.32) pM/min per ml, P for trend < 0.001, in normal weight, overweight and obese children, respectively]. In girls, night-time systolic BP (SBP) and diastolic BP (DBP) increased across tertiles of ACE activity (P < 0.001 and P = 0.002, respectively). ACE2 activity was associated with higher night-time SBP and DBP in overweight/obese girls (P = 0.037 and P = 0.048, respectively) and night-time DBP in the BMI z-score girl adjusted model (P = 0.018). Median ACE2 levels were significantly higher among nondipper girls (16.7 vs. 11.6 pM/min per ml, P = 0.009).Conclusions:Our work shows that obesity is associated with activation of the renin-angiotensin-aldosterone system, with significant increase of ACE and ACE2 activities already in childhood. Also, we report sex differences in the association of ACE and ACE2 activities with BP.
Dados da publicação
- ISSN/ISSNe:
- 1473-5598, 0263-6352
- Tipo:
- Article
- Páginas:
- 545-553
- Link para outro recurso:
- www.scopus.com
Journal of Hypertension Lippincott Williams and Wilkins Ltd.
Documentos
- Não há documentos
Filiações
Keywords
- angiotensin-converting enzyme; angiotensin-converting enzyme 2; obesity; renin-angiotensin-aldosterone system; sex
Campos de estudo
Financiamento
Proyectos asociados
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Citar a publicação
Gaspar AR,Andrade B,Mosca S,Ferreira M,Teixeira A,Cosme D,Albino A,Ronchi FA,Leite AP,Casarini DE,Areias J,Sousa T,Afonso AC,Morato M,Correia L. Association between blood pressure and angiotensin-converting enzymes activity in prepubertal children*. J. Hypertens. 2023. 41. (4):p. 545-553. IF:4,900. (2).
