Portal de investigação
Systematic review: gastric microbiota in health and disease
Autores da FMUP
Participantes de fora da FMUP
- Rajilic Stojanovic, M
- Smet, A
- Hansen, R
- Kupcinskas, J
- Rokkas, T
- Andersen, L
- Ianiro, G
- Gasbarrini, A
- Leja, M
- Gisbert, JP
- Hold, GL
Unidades de investigação
Abstract
Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.
Dados da publicação
- ISSN/ISSNe:
- 0269-2813, 1365-2036
- Tipo:
- Review
- Páginas:
- 582-602
- DOI:
- 10.1111/apt.15650
- Link para outro recurso:
- www.scopus.com
ALIMENTARY PHARMACOLOGY & THERAPEUTICS Wiley-Blackwell Publishing Ltd
Citações Recebidas na Web of Science: 92
Citações Recebidas na Scopus: 119
Documentos
- Não há documentos
Filiações
Keywords
- HELICOBACTER-PYLORI INFECTION; PROTON PUMP INHIBITORS; HUMAN GUT MICROBIOTA; INTESTINAL METAPLASIA; WEIGHT-LOSS; MOLECULAR CHARACTERIZATION; STOMACH MICROBIOTA; BARIATRIC SURGERY; BACTERIAL BIOTA; CANCER
Proyectos asociados
Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico (Helicobacter) . 2019
Citar a publicação
Rajilic M,Figueiredo C,Smet A,Hansen R,Kupcinskas J,Rokkas T,Andersen L,Machado J,Ianiro G,Gasbarrini A,Leja M,Gisbert JP,Hold GL. Systematic review: gastric microbiota in health and disease. Aliment. Pharmacol. Ther. 2020. 51(6):p. 582-602. IF:8,171. (1).
