Portal de investigação
Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Silva, MC
- Fernandes, A
- Oliveira, M
- Resende, C
- Correia, I.
- de Freitas, JC
- Lavelle, A
- Andrade da Costa, J
- Leander, M
- Xavier Ferreira, H
- Bessa, J
- Pereira, C
- Henrique, R.
- Marcos Pinto, R
- Lima, M
- Lepenies, B
- Sokol, H
- Vilanova, M.
- Pinho, SS
Unidades de investigação
Abstract
Tumor growth is accompanied with dramatic changes in the cellular glycome, such as the aberrant expression of complex branched N-glycans. However, the role of this protumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleashing an antitumor immune response remain elusive. We demonstrated that branched N-glycans are used by colorectal cancer cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFN gamma. The removal of this "glycan-mask" exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN-expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in colorectal cancer, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.
©2020 American Association for Cancer Research.
Dados da publicação
- ISSN/ISSNe:
- 2326-6066, 2326-6074
- Tipo:
- Article
- Páginas:
- 1407-1425
- Link para outro recurso:
- www.scopus.com
Cancer Immunology Research American Association for Cancer Research Inc.
Citações Recebidas na Web of Science: 28
Citações Recebidas na Scopus: 38
Documentos
- Não há documentos
Filiações
Keywords
- ANTITUMOR IMMUNITY; GLYCOSYLATION; BLOCKADE; TUMOR; STABILIZATION; INFLAMMATION; INNATE; ROLES; CELLS
Financiamento
Proyectos asociados
Effectiveness of endoscopic resection of colonic lesions > 20mm
Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico (Colonic lesions) . 2020
Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Silva MC,Fernandes A,Oliveira M,Resende C,Correia I,de Freitas JC,Lavelle A,Andrade da Costa J,Leander M,Xavier H,Bessa J,Pereira C,Henrique R,Carneiro F,Dinis M,Marcos R,Lima M,Lepenies B,Sokol H,Machado J,Vilanova M,Pinho SS. Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression. Cancer Immunol Res. 2020. 8. (11):p. 1407-1425. IF:11,151. (1).
