Portal de investigação
Immune Tumor Microenvironment in Ovarian Cancer Ascites
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Almeida-Nunes, DL
- Mendes-Frias, A
- Silvestre, R
- Ricardo, S
Unidades de investigação
Abstract
Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal organs. MA comprise cellular components with tumor and non-tumor cells and acellular components, creating a unique microenvironment capable of modifying the tumor behavior. These microenvironment factors influence tumor cell proliferation, progression, chemoresistance, and immune evasion, suggesting that MA play an active role in OC progression. Tumor cells induce a complex immune suppression that neutralizes antitumor immunity, leading to disease progression and treatment failure, provoking a tumor-promoting environment. In this review, we will focus on the High-Grade Serous Carcinoma (HGSC) microenvironment with special attention to the tumor microenvironment immunology.
Dados da publicação
- ISSN/ISSNe:
- 1661-6596, 1661-6596
- Tipo:
- Review
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
International Journal of Molecular Sciences Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 10
Citações Recebidas na Scopus: 23
Documentos
- Não há documentos
Filiações
Keywords
- ovarian cancer; malignant ascites; tumor microenvironment; immune cells; cytokines; high-grade serous carcinoma
Financiamento
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Citar a publicação
Almeida DL,Mendes A,Silvestre R,Dinis R,Ricardo S. Immune Tumor Microenvironment in Ovarian Cancer Ascites. Int. J. Mol. Sci. 2022. 23(18):10692. IF:5,600. (1).
