Portal de investigação
Research into toxicological mechanisms of tramadol and tapentadol: clinical and forensic aspects.
Dados básicos
- Código:
- Estudo Clínico Académico
- Protocolo:
- Estudo Clínico Académico
- EUDRACT:
- NCT:
- Centro:
- Dotação:
- Ano de início:
- 2019
- Ano de conclusão:
Objectivos do projeto
Estudos Observacionais (STROBE statement); Natureza do Promotor: Academia – Tipo não comercial – Iniciativa do Investigador; Tipo de Centro: Unicêntrico – Cuidados Secundários
Documentos
- Não há documentos
Participantes
Unidades de investigação
Stakeholders - Promotores
Outputs do ensaio clínico
``Not everything that can be counted counts'' in ethanol toxicological results: an antemortem and postmortem technical interpretation focusing on driving under the influence
Dinis-Oliveira, Ricardo Jorge
Review. 10.1093/fsr/owae023. 2024
Postmortem biochemical changes in multiple rat biological matrices and their correlation with the time of death
Andre, M. B.; (...); Dinis-Oliveira, R. J.
Meeting Abstract. 10.1016/j.toxlet.2022.07.277. 2022
20 years of real-world data to estimate chronic kidney disease prevalence and staging in an unselected population
Magalh?es, S.; (...); Dinis, R.
Article. 10.1093/ckj/sfac206. 2022
20 Years of Real-World Data to Estimate the Prevalence of Heart Failure and Its Subtypes in an Unselected Population of Integrated Care Units
Gavina, C.; (...); Taveira Gomes, T.
Article. 10.3390/jcdd9050149. 2022
20 Years of Real-World Data to Estimate the Prevalence of Heart Failure and Its Subtypes in an Unselected Population of Integrated Care Units.
Gavina, C; (...); Taveira-Gomes, T
Article. 2022
A fatal case by a suicide kit containing sodium nitrite ordered on the internet
Durao, C, Pedrosa, F, Dinis-Oliveira, RJ
Article. 10.1016/j.jflm.2020.101989. 2020
A pol?tica editorial da RevSALUS: passar os olhos no primeiro ano para construir o futuro
Dinis, R.
Article. 10.51126/revsalus.v2i1.107. 2020
A soil-based approach on human taphonomy from five Portuguese public cemeteries
Silva-Bessa, Angela; (...); Ferreira, Maria Teresa
Article. 10.1080/00450618.2023.2289378. 2023
A Suicide Attempt with a Velo-Dog Pocket Revolver in an Alleged Victim of Carjacking
Dur?o, C, Dinis, R.
Article. 10.3390/forensicsci2010008. 2022
Abuse of Licit and Illicit Psychoactive Substances in the Workplace: Medical, Toxicological, and Forensic Aspects
Dinis, R., Magalhaes, T
Review. 10.3390/jcm9030770. 2020
Acute liver failure requiring transplantation: A possible link to ulipristal acetate treatment?
Dinis, R., Vieira, DN
Article. 10.1111/bcpt.13631. 2021
An Overview of the Recent Advances in Antimicrobial Resistance
Oliveira, Manuela; (...); Dias da Silva, Diana
Review. 10.3390/microorganisms12091920. 2024
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
Soares, RB, Dinis, R., Oliveira, NG
Article. 10.3390/jcm11144039. 2022
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava.
Soares, RB, Dinis-Oliveira, RJ, Oliveira, NG
Review. 2022
Analysis of the autopsy, toxicological, and psychiatric reports of Portugal's first major forensic case: part III
Dinis, R.
Article. 10.1080/20961790.2021.1898079. 2021
Analysis of the testimonial evidence of Portugal's first major forensic case: part II
Dinis, R.
Article. 10.1080/20961790.2019.1682218. 2020
Another suicide by sodium nitrite and multiple drugs: an alarming trend for "exit"?
Durao, C, Pedrosa, F, Dinis-Oliveira, RJ
Editorial Material. 10.1007/s12024-020-00340-2. 2021
Assessment of the CYP450 inhibitory activity of psilocybin, psilocin, LSD, 5-MeO-DMT and mescaline: An in vitro study
Costa, A. M.; (...); Dias-da-Silva, D.
Meeting Abstract. 2023
Ayahuasca and N,N-dimethyltryptamine (DMT): Toxicokinetics, toxicodynamics, and biological effects
Madureira-Carvalho, A.; (...); Dinis-Oliveira, R. J.
Meeting Abstract. 10.1016/j.toxlet.2022.07.282. 2022
Bisphosphonates and osteonecrosis of the jaws: Clinical and forensic aspects
Nogueira, D, Caldas, IM, Dinis, R.
Article. 10.1016/j.archoralbio.2023.105792. 2023
Cadaveric ichthyofauna of the Madeira River in the Amazon basin: the myth of man-eating piranhas
Valente Aguiar, MS; (...); Dinis, R.
Article. 10.1007/s12024-020-00221-8. 2020
Cardiorenal Syndrome and Death Risk in Heart Failure or CKD Patients: An Urgent Call for Action
Santos Araujo, Carla Alexandra R.; (...); Gomes, Tiago Taveira
Meeting Abstract. 2022
Cardiorenal Syndrome and Kidney Disease Progression in Patients With Heart Failure or CKD: Is the Heart Leading the Way?
Santos Araujo, Carla Alexandra R.; (...); Gomes, Tiago Taveira
Meeting Abstract. 2022
Cardiovascular Risk Profile and Lipid Management in the Population-Based Cohort Study LATINO: 20 Years of Real-World Data
Gavina, C.; (...); Taveira Gomes, T.
Article. 10.3390/jcm11226825. 2022
Clinical and forensic aspects of potassium iodide: Suddenly in high demand across Europe due to fears of radiation poisoning from a nuclear attack in Ukraine
Lopes, Joao Pedro da Silva, Barbosa, Joana, Dinis-Oliveira, Ricardo Jorge
Review. 10.1111/bcpt.14052. 2024
Clinical and Forensic Aspects of the Different Subtypes of Argyria
Mota, L, Dinis-Oliveira, RJ
Review. 10.3390/jcm10102086. 2021
Clinical and Forensic Signs Resulting from Exposure to Heavy Metals and Other Chemical Elements of the Periodic Table
Machado, CD, Dinis, R.
Review. 10.3390/jcm12072591. 2023
Clinical and Forensic Signs Resulting from Exposure to Heavy Metals and Other Chemical Elements of the Periodic Table.
Machado, CD, Dinis-Oliveira, RJ
Review. 2023
Comment on Tomsia M. et al. Article "sodium nitrite detection in costal cartilage and vitreous humor - Case report of fatal poisoning with sodium nitrite"
Durao, C, Dinis-Oliveira, RJ
Article. 10.1016/j.jflm.2021.102200. 2021
Commentary on: Dean DE, Looman KB, Topmiller RG. Fatal methemoglobinemia in three suicidal sodium nitrite poisonings. J Forensic Sci. doi: 10.1111/1556-4029.14689. Epub 2021 Feb 17.
Dinis, R., Durao, C
Article. 10.1111/1556-4029.14723. 2021
Computerized delineation of the teeth and comparison with a smiling photograph: identification of a body skeletonized by cadaverous ichthyofauna action
Valente Aguiar, MS; (...); Dinis, R.
Editorial Material. 10.1007/s12024-021-00384-y. 2021
COVID-19 research: pandemic versus "paperdemic", integrity, values and risks of the "speed science"
Dinis, R.
Editorial Material. 10.1080/20961790.2020.1767754. 2020
CRISPR-Cas technology in forensic investigations: Principles, applications, and ethical considerations
Sobral, Ana Filipa, Dinis-Oliveira, Ricardo Jorge, Barbosa, Daniel Jose
Article. 10.1016/j.fsigen.2024.103163. 2025
ChatGPT in forensic sciences: a new Pandora’s box with advantages and challenges to pay attention.
Dinis-Oliveira, RJ, Azevedo, RMS
Article. 2023
ChatGPT in forensic sciences: a new Pandora's box with advantages and challenges to pay attention
Dinis, R., Azevedo, RMS
Article. 10.1093/fsr/owad039. 2023
Chemical elemental composition and human taphonomy: A comparative analysis between skeletonised and preserved individuals from six Portuguese public cemeteries
Silva-Bessa, Angela; (...); Dinis-Oliveira, Ricardo Jorge
Article. 10.1016/j.jtemb.2024.127551. 2024
Digital Health and Big Data Analytics: Implications of Real-World Evidence for Clinicians and Policymakers
Magalh?es, T., Dinis, R., Taveira Gomes, T.
Article. 10.3390/ijerph19148364. 2022
Early pathways of toxicity triggered by 3,4-methylene-dioxypyrovalerone unveiled by in vivo toxicometabolomics
Araujo, A. M.; (...); Carvalho, F.
Meeting Abstract. 2021
Enhancing Immunotherapy in Ovarian Cancer: The Emerging Role of Metformin and Statins
Almeida-Nunes, Diana Luisa; (...); Ricardo, Sara
Review. 10.3390/ijms25010323. 2024
Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis
Neves, I, Dinis, R., Magalhaes, T
Review. 10.1080/20961790.2019.1641954. 2021
Fatal iatrogenic cardiac tamponade due to central venous catheterization
Valente Aguiar, MS; (...); Dinis, R.
Article. 10.1007/s12024-022-00491-4. 2022
Forensic Sciences: The Genesis of a New Open Access Journal Focused on the Latest Scientific Advances
Dinis, R.
Article. 10.3390/forensicsci1010001. 2020
Forensic significance of postmortem pink teeth: A narrative review
Braga, Susana, Caldas, Ines Morais, Dinis-Oliveira, Ricardo Jorge
Review. 10.1016/j.archoralbio.2024.106092. 2025
Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review
Oliveira, NG, Ramos, DL, Dinis, R.
Review. 10.1007/s00204-020-02926-9. 2021
Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
Naghavi, Mohsen; (...); Murray, Christopher J. L.
Article. 10.1016/S0140-6736(24)00367-2. 2024
Greenish-blue discoloration of the brain and heart after treatment with methylene blue
Durao, C, Pedrosa, F, Dinis, R.
Article. 10.1007/s12024-020-00316-2. 2020
Health Outcomes in Women Victims of Intimate Partner Violence: A 20-Year Real-World Study
Clemente-Teixeira, M; (...); Taveira Gomes, T.
Article. 10.3390/ijerph192417035. 2022
Health Outcomes in Women Victims of Intimate Partner Violence: A 20-Year Real-World Study.
Clemente-Teixeira, M; (...); Taveira-Gomes, T
Article. 2022
Immune Tumor Microenvironment in Ovarian Cancer Ascites
Almeida-Nunes, DL; (...); Ricardo, S
Review. 10.3390/ijms231810692. 2022
Immune Tumor Microenvironment in Ovarian Cancer Ascites.
Almeida-Nunes, DL; (...); Ricardo, S
Review. 2022
In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV)
Araújo, AM; (...); Carvalho, F.
Article. 10.1007/s00204-020-02949-2. 2021
Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis
Araujo, Marta; (...); Silvestre, Ricardo
Article. 10.1111/imm.13686. 2023
Looking back, thanking authors and reviewers, and envisioning the future of RevSALUS
Dinis, R.; (...); Conde, J
Article. 10.51126/revsalus.v4i1.226. 2022
Looking back, thanking authors and reviewers, and envisioning the future of RevSALUS.
Dinis-Oliveira, RJ; (...); Conde, J
Article. 2022
Magic mushrooms and psilocybin: pharmacokinetics, pharmacodynamics, and clinical applications
da Silva, D. Dias; (...); Madureira-Carvalho, A.
Meeting Abstract. 10.1016/j.toxlet.2022.07.283. 2022
Mathematical Modelling Using Predictive Biomarkers for the Outcome of Canine Leishmaniasis upon Chemotherapy
Goncalves, RD; (...); Barrouin Melo, SM
Article. 10.3390/microorganisms8050745. 2020
Metabolomics and proteomics in occupational medicine: a comprehensive systematic review
Ochoa-Leite, Carlos; (...); Costa, Jose Torres
Review. 10.1186/s12995-024-00436-3. 2024
Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines
Almeida-Nunes, DL; (...); Ricardo, S
Article. 10.3390/ijms252211935. 2024
No Boundaries for Toxicology in Clinical Medicine: One Health, One Society and One Planet for All of Us
Dinis, R.
Editorial Material. 10.3390/jcm12082808. 2023
Nutritional adjuvants with antioxidant properties in the treatment of canine leishmaniasis
Gonçalves, RD; (...); Barrouin-Melo, SM
Article. 10.1016/j.vetpar.2021.109526. 2021
One image is value more than a thousand words: producing an atlas of medical signs for teaching clinical and forensic toxicology
Dinis-Oliveira, R. J.
Meeting Abstract. 10.1016/j.toxlet.2022.07.269. 2022
One image is worth more than a thousand words: producing an atlas of medical signs for teaching clinical and forensic toxicology
Dinis, R.
Article. 10.1080/20961790.2022.2059837. 2022
Os resultados positivos versus os resultados negativos em ci?ncia: uma breve reflex?o em benef?cio da integridade cient?fica
Dinis, R.AB -
Article. 10.51126/revsalus.v2i2.128. 2021
Ovarian cancer ascites proteomic profile reflects metabolic changes during disease progression
Almeida-Nunes, Diana Luisa; (...); Ricardo, Sara
Article. 10.1016/j.bbrep.2024.101755. 2024
Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications
Lobato-Freitas, C; (...); Dias-da-Silva, D
Review. 10.3390/ph14030186. 2021
Paving the way forward: Escherichia coli bacteriophages in a One Health approach
Oliveira, A; (...); Oliveira, H
Article. 10.1080/1040841x.2022.2161869. 2023
Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects
Sousa, A, Dinis, R.
Article. 10.1080/08897077.2019.1700584. 2020
Pharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
Silva, AR, Dinis, R.
Review. 10.1080/03602532.2020.1758712. 2020
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
Brito da Costa, AM; (...); Madureira Carvalho, A
Review. 10.3390/ph14020116. 2021
Pharmacokinetics, toxicological and clinical aspects of ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity
Dinis, R.
Article. 10.1080/03602532.2021.1917599. 2021
Postmortem degradation of mRNA transcripts in rat tissues and their correlation with time of death
Bernardes Andre, M.; (...); Dinis-Oliveira, R. J.
Meeting Abstract. 2023
Predatory journals and meetings in forensic sciences: what every expert needs to know about this "parasitic" publishing model
Dinis-Oliveira, RJ
Article. 10.1080/20961790.2021.1989548. 2021
Premature Mortality in Type 2 Diabetes Mellitus Associated with Heart Failure and Chronic Kidney Disease: 20 Years of Real-World Data
Gavina, C.; (...); Taveira Gomes, T.
Article. 10.3390/jcm11082131. 2022
Premature Mortality in Type 2 Diabetes Mellitus Associated with Heart Failure and Chronic Kidney Disease: 20 Years of Real-World Data.
Gavina, C; (...); Taveira-Gomes, T
Article. 2022
Raising Awareness on the Clinical and Forensic Aspects of Jellyfish Stings: A Worldwide Increasing Threat
Cunha, SA, Dinis, R.
Review. 10.3390/ijerph19148430. 2022
Raising Awareness on the Clinical and Forensic Aspects of Jellyfish Stings: A Worldwide Increasing Threat.
Cunha, SA, Dinis-Oliveira, RJ
Review. 2022
Reconstructed Human Epidermis: An Alternative Approach for In Vitro Bioequivalence Testing of Topical Products
Agonia, AS; (...); Palmeira-de-Oliveira, R
Article. 10.3390/pharmaceutics14081554. 2022
Reconstructed Human Epidermis: An Alternative Approach for In Vitro Bioequivalence Testing of Topical Products.
Agonia, AS; (...); Palmeira-de-Oliveira, R
Article. 2022
Repeated Administration of Clinical Doses of Tramadol and Tapentadol Causes Hepato- and Nephrotoxic Effects in Wistar Rats
Barbosa, J; (...); Dinis, R.
Article. 10.3390/ph13070149. 2020
Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats
Barbosa, J; (...); Dinis, R.
Article. 10.3390/ph14020097. 2021
Reply to the commentary by Sarode and Sarode on "Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review"
Oliveira, NG, Ramos, DL, Dinis-Oliveira, RJ
Article. 10.1007/s00204-021-03039-7. 2021
Simultaneous detection and quantification of psilocybin and psilocin by gas chromatography coupled to mass spectrometry (GC-MS)
Brito-da-Costa, A. M.; (...); da Silva, D. Dias
Meeting Abstract. 10.1016/j.toxlet.2022.07.280. 2022
Single-camera photogrammetry using a mobile phone for low-cost documentation of corpses
Valente-Aguiar, Murilo Sergio; (...); Dinis-Oliveira, Ricardo Jorge
Article. 10.1007/s00414-024-03271-7. 2024
Suicide by inhalation of butane gas through a homemade adaptation of a continuous positive airway pressure (CPAP) face mask
Durao, C, Pedrosa, F, Dinis, R.
Article. 10.1007/s12024-020-00271-y. 2020
The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
Mesquita, I; (...); Silvestre, R
Article. 10.1016/j.celrep.2020.02.098. 2020
The Auto-Brewery Syndrome: A Perfect Metabolic "Storm" with Clinical and Forensic Implications
Dinis, R.
Review. 10.3390/jcm10204637. 2021
The Future Is Now: Unraveling the Expanding Potential of Human (Necro)Microbiome in Forensic Investigations
Cláudia-Ferreira, A; (...); Freitas, AR
Review. 10.3390/microorganisms11102509. 2023
The Future Is Now: Unraveling the Expanding Potential of Human (Necro)Microbiome in Forensic Investigations.
Cláudia-Ferreira, A; (...); Freitas, AR
Review. 2023
The Link Between Paraquat and Demyelination: A Review of Current Evidence
Silva, Renata; (...); Barbosa, Daniel Jose
Review. 10.3390/antiox13111354. 2024
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
Brito da Costa, AM; (...); Madureira Carvalho, A
Review. 10.3390/ph13110334. 2020
Tramadol and Tapentadol Induce Conditioned Place Preference with a Differential Impact on Rewarding Memory and Incubation of Craving
Barbosa, J; (...); Faria, J
Article. 10.3390/ph16010086. 2023
Tramadol and Tapentadol Induce Conditioned Place Preference with a Differential Impact on Rewarding Memory and Incubation of Craving.
Barbosa, J; (...); Faria, J
Article. 2023
Unraveling the Hippocampal Molecular and Cellular Alterations behind Tramadol and Tapentadol Neurobehavioral Toxicity
Soares-Cardoso, Cristiana; (...); Barbosa, Joana
Article. 10.3390/ph17060796. 2024
When the antidote for cyanide poisonings becomes a nightmare: an alarming outbreak of suicides using kits containing sodium nitrite
Dinis, R., Durao, C
Article. 10.1093/fsr/owad015. 2023
