Portal de investigação
The Future Is Now: Unraveling the Expanding Potential of Human (Necro)Microbiome in Forensic Investigations
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Cláudia-Ferreira, A
- Barbosa, DJ
- Saegeman, V
- Fernández-Rodríguez, A
- Freitas, AR
- ESCMID Study Grp Forensic Post
Unidades de investigação
Abstract
The relevance of postmortem microbiological examinations has been controversial for decades, but the boom in advanced sequencing techniques over the last decade is increasingly demonstrating their usefulness, namely for the estimation of the postmortem interval. This comprehensive review aims to present the current knowledge about the human postmortem microbiome (the necrobiome), highlighting the main factors influencing this complex process and discussing the principal applications in the field of forensic sciences. Several limitations still hindering the implementation of forensic microbiology, such as small-scale studies, the lack of a universal/harmonized workflow for DNA extraction and sequencing technology, variability in the human microbiome, and limited access to human cadavers, are discussed. Future research in the field should focus on identifying stable biomarkers within the dominant Bacillota and Pseudomonadota phyla, which are prevalent during postmortem periods and for which standardization, method consolidation, and establishment of a forensic microbial bank are crucial for consistency and comparability. Given the complexity of identifying unique postmortem microbial signatures for robust databases, a promising future approach may involve deepening our understanding of specific bacterial species/strains that can serve as reliable postmortem interval indicators during the process of body decomposition. Microorganisms might have the potential to complement routine forensic tests in judicial processes, requiring robust investigations and machine-learning models to bridge knowledge gaps and adhere to Locard's principle of trace evidence.
Dados da publicação
- ISSN/ISSNe:
- 2076-2607, 2076-2607
- Tipo:
- Review
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Microorganisms MDPI AG
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 9
Documentos
- Não há documentos
Filiações
Keywords
- microbiome; necrobiome; thanatomicrobiome; decomposition; bacteria; postmortem
Financiamento
Proyectos asociados
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Citar a publicação
Cláudia A,Barbosa DJ,Saegeman V,Fernández A,Dinis RJ,Freitas AR,ESCMID Study Forensic Post GRP. The Future Is Now: Unraveling the Expanding Potential of Human (Necro)Microbiome in Forensic Investigations. Microorg. 2023. 11(10):2509. IF:4,500. (2).
