Portal de investigação
Exosomal glypican-1 discriminates pancreatic ductal adenocarcinoma from chronic pancreatitis
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Moutinho Ribeiro, P
- Adem, B
- Batista, I
- Silva, M
- Silva, S
- Ruivo, CF
- Morais, R
- Peixoto, A
- Coelho, R
- Costa Moreira, P
- Lopes, S
- Vilas Boas, F
- Duraes, C
- Lopes, J
- Barroca, H
- Melo, SA
Unidades de investigação
Abstract
Background and aims: Pancreatic ductal adenocarcinoma (PDAC) diagnosis can be difficult in a chronic pancreatitis (CP) background, especially in its mass forming presentation. We aimed to assess the accuracy of glypican-1-positive circulating exosomes (GPC1+ crExos) to distinguish PDAC from CP versus the state-of-the-art CA 19-9 biomarker. Methods: This was a unicentric prospective cohort. Endoscopic ultrasound with fine-needle aspiration or biopsy and blood tests (GPC1+ crExos and serum CA 19-9) were performed. Results: The cohort comprised 60 PDAC and 29 CP (7 of which mass forming - MF) patients. Median levels of GPC1+ crExos were significantly higher in PDAC (99.7%) versus CP (28.4%; p<0.00 01) with an AUROC of 0.96 with 98.3% sensitivity and 86.2% specificity for a cut-offof 45.0% (p<0.0 001); this outperforms CA 19-9 AUROC of 0.82 with 78.3% sensitivity and 65.5% specificity at a cut-offof 37 U/mL (p<0.0 001). The superiority of% GPC1+crExos over CA 19-99 in differentiating PDAC from CP was observed in both early (stage I) and advanced tumors (stages II-IV). Conclusion: Levels of GPC1+ crExos coupled to beads enable differential diagnosis between PDAC and CP including its mass-forming presentation. (C) 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 1590-8658, 1878-3562
- Tipo:
- Article
- Páginas:
- 871-877
- Link para outro recurso:
- www.scopus.com
Digestive and Liver Disease Elsevier
Citações Recebidas na Web of Science: 5
Citações Recebidas na Scopus: 12
Documentos
- Não há documentos
Filiações
Keywords
- Chronic pancreatitis; Glypican-1; CA 199; Endoscopic ultrasound; Pancreatic ductal adenocarcinoma
Financiamento
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Citar a publicação
Moutinho P,Adem B,Batista I,Silva M,Silva S,Ruivo CF,Morais R,Peixoto A,Coelho R,Costa P,Lopes S,Vilas F,Duraes C,Lopes J,Barroca H,Carneiro F,Melo SA,Macedo G. Exosomal glypican-1 discriminates pancreatic ductal adenocarcinoma from chronic pancreatitis. Dig. Liver Dis. 2022. 54. (7):p. 871-877. IF:4,500. (2).
