Portal de investigação
Epstein-Barr virus status drives morphological and molecular intra-tumour heterogeneity in gastric cancer: insights from a case report and literature review
Autores da FMUP
Participantes de fora da FMUP
- Sacramento, Maria Luisa
- Morais, Rui
- Kim, Yongsoo
- Eijk, Paul P.
- Rocha, Ana Mafalda
- Baptista, Diana
- Santos-Antunes, Joao
- Ylstra, Bauke
Unidades de investigação
Abstract
This case report describes a rare case of bi-phenotypic gastric cancer with two distinct, but clonally related, histological components. The first component, associated with Epstein-Barr virus (EBV) infection, exhibited the morphological features of gastric carcinoma with lymphoid stroma, suggesting that EBV, as an effective immunogenic factor, may trigger a prominent immune response within the tumour microenvironment. The second component, which was EBV-negative, displayed tubular/papillary morphology and features of increased biological aggressiveness, such as high-grade areas and lymphatic invasion. Immunohistochemical and molecular studies confirmed that, despite the differing morphologies and immunophenotypes, both components were clonally related, with the EBV-negative area showing more complex DNA aberrations, reminiscent of chromosomally instable (CIN) lesions. This case describes clonally related EBV-positive and -negative components within a single gastric cancer, contributing to a better understanding of EBV role in tumour heterogeneity and progression and highlights the impact of EBV loss on tumour behaviour.
Dados da publicação
- ISSN/ISSNe:
- 0945-6317, 1432-2307
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
VIRCHOWS ARCHIV Springer Verlag
Documentos
- Não há documentos
Filiações
Keywords
- Gastric cancer with lymphoid stroma; Epstein-Barr virus infection; Copy number analysis; Intra-tumour heterogeneity
Campos de estudo
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Estudo Clínico Académico . 2021
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Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Gullo I,Sacramento ML,Morais R,Kim Y,Eijk PP,Rocha AM,Baptista D,Santos J,Ylstra B,Carneiro F. Epstein-Barr virus <i>status</i> drives morphological and molecular intra-tumour heterogeneity in gastric cancer: insights from a case report and literature review. Virchows Arch. 2025. IF:3,500. (2).
