Autoimmune hepatitis and eosinophilia: A rare case report

Autores da FMUP

• Susana Isabel Oliveira Lopes

  Autor

• Maria De Fátima Machado Henriques Carneiro

  Autor

• Manuel Guilherme Gonçalves Macedo

  Autor

Participantes de fora da FMUP

• Garrido, I
• Fonseca, E

Unidades de investigação

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• Patologia

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

BACKGROUND Autoimmune hepatitis consists of a chronic liver disease whose etiology is unknown. It is comprised of relevant immunological aspects and of immune-mediated liver injury. Eosinophilia may be a considerable feature, particularly happening in male patients.CASE SUMMARY We report here a Crohn's disease patient presenting with de novo hypergammaglobulinemia, circulating autoantibodies and elevated transaminase levels. He also had significant peripheral eosinophilia and elevated immunoglobulin E levels at diagnosis. The pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic infiltration.CONCLUSION This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow, described in a patient with Crohn's disease.

Keywords

• Autoimmune hepatitis; Eosinophilia; Bone marrow; Crohn's disease; Case report