Portal de investigação
Histologic Features of Syphilitic Gastritis A Rare but Resurging Imitator of Common Diseases
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Assarzadegan, N
- Fang, JM
- Voltaggio, L
- Riddell, RH
- Montgomery, EA
- McDonald, OG
- Coates, R
- Lauwers, GY
- Kamionek, M
- Lamps, LW
- Westerhoff, M
Unidades de investigação
Abstract
Objectives The range of histopathologic features of gastric syphilis is not well described. Here we describe the clinicopathologic findings of eight patients with syphilitic gastritis. Methods A search of our Pathology Data System (2003-2022) and multiple other institutions identified eight patients with syphilitic gastritis. Clinical information, pathology reports, and available slides were reviewed. Results Lesions predominated in middle-aged adults (mean age, 47.2 years; range, 23-61 years) with a propensity for men (n = 7). Three patients had a documented history of human immunodeficiency virus. Clinical presentations included weight loss, abdominal pain, hematochezia, fever, dyspepsia, nausea and vomiting, hematemesis, anemia, and early satiety. Endoscopic findings included ulcerations, erosions, abnormal mucosa, and nodularity. All specimens shared an active chronic gastritis pattern with intense lymphohistiocytic infiltrates, variable plasma cells, and gland loss. Prominent lymphoid aggregates were seen in four specimens. The diagnosis was confirmed either by immunostain for Treponema pallidum (n = 7) or by direct immunofluorescence staining and real-time polymerase chain reaction (n = 1). All patients with available follow-up data showed resolution of symptoms after antibiotic therapy (n = 4). Conclusions Recognition of the histologic pattern of syphilitic gastritis facilitates timely treatment, prevents further transmission, and avoids unnecessarily aggressive treatment.
Dados da publicação
- ISSN/ISSNe:
- 1943-7722, 0002-9173
- Tipo:
- Article
- Páginas:
- 263-273
- DOI:
- 10.1093/ajcp/aqac153
- Link para outro recurso:
- www.scopus.com
American Journal of Clinical Pathology Oxford University Press
Citações Recebidas na Web of Science: 2
Citações Recebidas na Scopus: 2
Documentos
- Não há documentos
Filiações
Keywords
- Human immunodeficiency virus (HIV); Syphilis; Treponema pallidum; Gastritis; Lymphoma; Men who have sex with men (MSM); Gastric pathology
Campos de estudo
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Citar a publicação
Assarzadegan N,Fang JM,Voltaggio L,Riddell RH,Montgomery EA,McDonald OG,Coates R,Carneiro F,Lauwers GY,Kamionek M,Lamps LW,Westerhoff M. Histologic Features of Syphilitic Gastritis A Rare but Resurging Imitator of Common Diseases. Am. J. Clin. Pathol. 2023. 159. (3):p. 263-273. IF:3,500. (2).
