Portal de investigação
Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Pereira, C
- Park, JH
- Campelos, S
- Lemos, C
- Solorzano, L
- Martins, D
- Gonçalves, G
- Lee, HJ
- Kong, SH
- Andre, A
- Borges, C
- Almeida, D
- Wälbhy, C
- Almeida, R.
- Kim, WH
- Yang, HK
- Almeida, GM
Unidades de investigação
Abstract
Surgical resection with lymphadenectomy and perioperative chemotherapy is the universal mainstay for curative treatment of gastric cancer (GC) patients with locoregional disease. However, GC survival remains asymmetric in West- and East-world regions. We hypothesize that this asymmetry derives from differential clinical management. Therefore, we collected chemo-naive GC patients from Portugal and South Korea to explore specific immunophenotypic profiles related to disease aggressiveness and clinicopathological factors potentially explaining associated overall survival (OS) differences. Clinicopathological and survival data were collected from chemo-naive surgical cohorts from Portugal (West-Europe cohort [WE-C]; n = 170) and South Korea (East-Asia cohort [EA-C]; n = 367) and correlated with immunohistochemical expression profiles of E-cadherin and CD44v6 obtained from consecutive tissue microarrays sections. Survival analysis revealed a subset of 12.4% of WE-C patients, whose tumors concomitantly express E-cadherin_abnormal and CD44v6_very high, displaying extremely poor OS, even at TNM stages I and II. These WE-C stage-I and -II patients tumors were particularly aggressive compared to all others, invading deeper into the gastric wall (P = .032) and more often permeating the vasculature (P = .018) and nerves (P = .009). A similar immunophenotypic profile was found in 11.9% of EA-C patients, but unrelated to survival. Tumours, from stage-I and -II EA-C patients, that display both biomarkers, also permeated more lymphatic vessels (P = .003), promoting lymph node (LN) metastasis (P = .019), being diagnosed on average 8 years earlier and submitted to more extensive LN dissection than WE-C. Concomitant E-cadherin_abnormal/CD44v6_very-high expression predicts aggressiveness and poor survival of stage-I and -II GC submitted to conservative lymphadenectomy.
Dados da publicação
- ISSN/ISSNe:
- 0020-7136, 1097-0215
- Tipo:
- Article
- Páginas:
- 868-880
- DOI:
- 10.1002/ijc.33872
- Link para outro recurso:
- www.scopus.com
International Journal of Cancer Wiley-Liss Inc.
Citações Recebidas na Web of Science: 7
Citações Recebidas na Scopus: 8
Documentos
- Não há documentos
Filiações
Keywords
- CD44; early detection of cancer; E-cadherin; lymph node excision; tumor tomography
Financiamento
Proyectos asociados
The role of hepatocyte apoptosis markers in predicting the histological and serological activity in steatohepatitis
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2021
E-cadherin and CD44v6 in Gastric Cancer: Role, crosstalk and clinical implications
Investigador Principal: Carla Isabel Gonçalves de Oliveira
Estudo Clínico Académico . 2021
Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Pereira C,Park JH,Campelos S,Gullo I,Lemos C,Solorzano L,Martins D,Gonçalves G,Leitao D,Lee HJ,Kong SH,Andre A,Borges C,Almeida D,Wälbhy C,Almeida R,Kim WH,Carneiro F,Yang HK,Almeida GM,Oliveira C. Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness. Int. J. Cancer. 2022. 150. (5):p. 868-880. IF:6,400. (1).
